Description
Anti-IgA in the IgG class are specific IgG antibodies against immunoglobulin A. Patients with IgA deficiency often demonstrate circulating antibodies against IgA, which have been suggested to be associated with transfusion reactions. Anti-IgA antibodies occur in about 10% of patients with selective IgA deficiency (IgAD) and are detected approximately in the same percentage of patients with Common Variable Immunodeficiency (CVID). Patients with anti-IgA antibodies are at risk to develop an anaphylactoid reaction to substitution gamma globulin treatment, especially upon intravenous administration